Dai Z, Ramesh V, Locasale JW., 2020. The evolving metabolic landscape of chromatin biology and epigenetics. Nature Reviews Genetics. Sep 9. doi: 10.1038/s41576-020-0270-8.

Bose S, Allen A, Locasale JW., 2020. The Molecular Link from Dietto Cancer Cell Metabolism. Molecular Cell. June

Ke W, Saba JA, Yao CH, Hilzendeger MA, Drangowska-Way A, Joshi C, Mony VK, Benjamin SB, Zhang S, Locasale J, Patti GJ, Lewis N, O'Rourke EJ., 2020. Dietary Serine-Microbiota Interaction Enhances Chemotherapeutic Toxicity Without Altering Drug Conversion. Nature Communications. May 22;11(1):2587. doi: 10.1038/s41467-020-16220-w.

Ramesh V, Locasale JW., 2020. A Reactive Metabolite as an Immune Suppressant. Nature Immunology. May;21(5):497-498. doi: 10.1038/s41590-020-0664-y.

Lin KH, Rutter JC, Xie A, Pardieu B, Winn ET, Bello RD, Forget A, Itzykson R, Ahn YR, Dai Z, Sobhan RT, Anderson GR, Singleton KR, Decker AE, Winter PS, Locasale JW, Crawford L, Puissant A, Wood KC., 2020. Using Antagonistic Pleiotropy to Design a Chemotherapy-Induced Evolutionary Trap to Target Drug Resistance in Cancer. Nature Genetics. Apr;52(4):408-417. doi: 10.1038/s41588-020-0590-9.


Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA., 2020. Transcriptional Diversity and Bioenergetic Shift in Human Breast Cancer Metastasis Revealed by Single-Cell RNA Sequencing. Nature Cell Biology. Mar;22(3):310-320. doi: 10.1038/s41556-020-0477-0.

Shats I, Williams JG, Liu J, Makarov MV, Wu X, Lih FB, Deterding LJ, Lim C, Xu X, Randall TA, Lee E, Li W, Fan W, Li JL, Sokolsky M, Kabanov AV, Li L, Migaud ME, Locasale JW, Li X., 2020. Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway. Cell Metabolism. Mar 3;31(3):564-579.e7. doi: 10.1016/j.cmet.2020.02.001.


Xiao Z, Locasale JW, Dai Z., 2020. Metabolism in the Tumor Microenvironment: Insights From Single-Cell Analysis. Oncoimmunology. Feb 9;9(1):1726556. doi: 10.1080/2162402X.2020.1726556.

Rumala CZ, Liu J, Locasale JW, Corkey BE, Deeney JT, Rameh LE., 2020. Exposure of Pancreatic β-Cells to Excess Glucose Results in Bimodal Activation of mTORC1 and mTOR-Dependent Metabolic Acceleration. iScience. Feb 21;23(2):100858. doi: 10.1016/j.isci.2020.100858.

Quek LE, Krycer JR, Ohno S, Yugi K, Fazakerley DJ, Scalzo R, Elkington SD, Dai Z, Hirayama A, Ikeda S, Shoji F, Suzuki K, Locasale JW, Soga T, James DE, Kuroda S., 2020. Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin. iScience. Feb 21;23(2):100855. doi: 10.1016/j.isci.2020.100855.

Tang S, Li X, Locasale JW., 2020. Dietary Methionine in T Cell Biology and Autoimmune Disease. Cell Metabolism. Feb 4;31(2):211-212. doi: 10.1016/j.cmet.2020.01.007.

Britt EC, John SV, Locasale JW, Fan J., 2020. Metabolic Regulation of Epigenetic Remodeling in Immune Cells. Current Opinion in Biotechnology. Jan 15;63:111-117. doi: 10.1016/j.copbio.2019.12.008.

Liberti MV, Locasale JW., 2020. Histone Lactylation: A New Role for Glucose Metabolism. Trends in Biochemical Sciences. Mar;45(3):179-182. doi: 10.1016/j.tibs.2019.12.004.

Liberti MV, Allen AE, Ramesh V, Dai Z, Singleton KR, Guo Z, Liu JO, Wood KC, Locasale JW., 2020. Evolved Resistance to Partial GAPDH Inhibition Results in Loss of the Warburg Effect and in a Different State of Glycolysis. Journal of Biological Chemistry. Jan 3;295(1):111-124. doi: 10.1074/jbc.RA119.010903.


Zurlo G, Liu X, Takada M, Fan C, Simon JM, Ptacek TS, Rodriguez J, von Kriegsheim A, Liu J, Locasale JW, Robinson A, Zhang J, Holler JM, Kim B, Zikánová M, Bierau J, Xie L, Chen X, Li M, Perou CM, Zhang Q., 2019. Prolyl Hydroxylase Substrate Adenylosuccinate Lyase Is an Oncogenic Driver in Triple Negative Breast Cancer. Nature Communications. Nov 15;10(1):5177. doi: 10.1038/s41467-019-13168-4.

Tabilas C, Wang J, Liu X, Locasale JW, Smith NL, Rudd BD., 2019. Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8 + T Cells in Early Life. Journal of Immunology. Nov 15;203(10):2571-2576. doi: 10.4049/jimmunol.1900426.

Guo Z, Cheng Z, Wang J, Liu W, Peng H, Wang Y, Rao AVS, Li RJ, Ying X, Korangath P, Liberti MV, Li Y, Xie Y, Hong SY, Schiene-Fischer C, Fischer G, Locasale JW, Sukumar S, Zhu H, Liu JO., 2019. Discovery of a Potent GLUT Inhibitor From a Library of Rapafucins by Using 3D Microarrays. Angewandte Chemie International Edition. Nov 25;58(48):17158-17162. doi: 10.1002/anie.201905578.

Sanderson SM, Gao X, Dai Z, Locasale JW., 2019. Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nature Reviews Cancer. Sep 12. doi: 10.1038/s41568-019-0187-8.

Xiao Z, Dai Z, Locasale JW., 2019. Metabolic landscape of the tumor microenvironment at single cell resolution. Nature Communications, Aug 21;10(1):3763. doi: 10.1038/s41467-019-11738-0.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Synder NW, Horng T., 2019. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology, doi: 10.1038/s41590-019-0453-7.

Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW., 2019. Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature, doi: 10.1038/s41586-019-1437-3.

Sanderson SM, Mikhael PG, Ramesh V, Dai Z, Locasale JW., 2019. Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells. Science Advances, 5(6):eaav7769.

Park S, Safi R, Liu X, Baldi R, Liu W, Liu J, Locasale JW, Chang CY, McDonnell DP., 2019. Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer. Cell Reports, 27(12):3587-3601.e4.

Bose S, Ramesh V, Locasale JW., 2019. Acetate Metabolism in Physiology, Cancer, and Beyond. Trends in Cell Biology, pii: S0962-8924(19)30084-4.

Locasale, J.W., 2018. New concepts in feedback regulation of glucose metabolism. Current Opinion in Systems Biology, 8, pp.32-38.


Vodnala, S.K., Eil, R., Kishton, R.J., Sukumar, M., Yamamoto, T.N., Ha, N.H., Lee, P.H., Shin, M., Patel, S.J., Yu, Z. and Palmer, D.C., 2019. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science, 363(6434), p.eaau0135.


Sinclair, L.V., Howden, A.J., Brenes, A., Spinelli, L., Hukelmann, J.L., Macintyre, A.N., Liu, X., Thomson, S., Taylor, P.M., Rathmell, J.C. and Locasale, J.W., 2019. Antigen receptor control of methionine metabolism in T cells. eLife, 8, p.e44210.


Gao, X., Locasale, J.W. and Reid, M.A., 2019. Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer. Cancer cell, 35(3), pp.339-341.


Lee, J., Yesilkanal, A.E., Wynne, J.P., Frankenberger, C., Liu, J., Yan, J., Elbaz, M., Rabe, D.C., Rustandy, F.D., Tiwari, P. and Grossman, E.A., 2019. Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. Nature, p.1.


Yang, Y., Gabra, M.B.I., Hanse, E.A., Lowman, X.H., Tran, T.Q., Li, H., Milman, N., Liu, J., Reid, M.A., Locasale, J.W. and Gil, Z., 2019. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nature communications, 10(1), p.809.


Gemta, L.F., Siska, P.J., Nelson, M.E., Gao, X., Liu, X., Locasale, J.W., Yagita, H., Slingluff, C.L., Hoehn, K.L., Rathmell, J.C. and Bullock, T.N., 2019. Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. Science immunology, 4(31), p.eaap9520.


May, J.L., Kouri, F.M., Hurley, L.A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A.E., Lee, A., Chandel, N.S. and Davuluri, R.V., 2019. IDH3α regulates one-carbon metabolism in glioblastoma. Science advances, 5(1), p.eaat0456.


Curtis, M., Kenny, H.A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N. and Gao, X., 2019. Fibroblasts mobilize tumor cell glycogen to promote proliferation and metastasis. Cell metabolism, 29(1), pp.141-155.



Hwang, I., Oh, H., Santo, E., Kim, D.Y., Chen, J.W., Bronson, R.T., Locasale, J.W., Na, Y., Lee, J., Reed, S. and Toth, M., 2018. FOXO protects against age‐progressive axonal degeneration. Aging cell, 17(1), p.e12701.


Zhao, F., Xiao, C., Evans, K.S., Theivanthiran, T., DeVito, N., Holtzhausen, A., Liu, J., Liu, X., Boczkowski, D., Nair, S. and Locasale, J.W., 2018. Paracrine wnt5a-β-catenin signaling triggers a metabolic program that drives dendritic cell tolerization. Immunity, 48(1), pp.147-160.


Allen, A.E. and Locasale, J.W., 2018. Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. Cancer cell, 33(3), pp.337-339.


Gao, X., Lee, K., Reid, M.A., Sanderson, S.M., Qiu, C., Li, S., Liu, J. and Locasale, J.W., 2018. Serine availability influences mitochondrial dynamics and function through lipid metabolism. Cell reports, 22(13), pp.3507-3520.


Yan, W., Wu, X., Zhou, W., Fong, M.Y., Cao, M., Liu, J., Liu, X., Chen, C.H., Fadare, O., Pizzo, D.P. and Wu, J., 2018. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nature cell biology, 20(5), p.597.


Hershberger, K.A., Abraham, D.M., Liu, J., Locasale, J.W., Grimsrud, P.A. and Hirschey, M.D., 2018. Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. Journal of Biological Chemistry, 293(27), pp.10630-10645.


Dai, Z., Mentch, S.J., Gao, X., Nichenametla, S.N. and Locasale, J.W., 2018. Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width. Nature communications, 9(1), p.1955.


Huang, H., Tang, S., Ji, M., Tang, Z., Shimada, M., Liu, X., Qi, S., Locasale, J.W., Roeder, R.G., Zhao, Y. and Li, X., 2018. EP300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis. Molecular cell, 70(4), pp.663-678.


Chapman, N.M., Zeng, H., Nguyen, T.L.M., Wang, Y., Vogel, P., Dhungana, Y., Liu, X., Neale, G., Locasale, J.W. and Chi, H., 2018. mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. Nature communications, 9.


Bechard, M.E., Word, A.E., Tran, A.V., Liu, X., Locasale, J.W. and McDonald, O.G., 2018. Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases. Oncogene, 37(38), p.5248.


Curtis, M., Kenny, H.A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N. and Gao, X., 2019. Fibroblasts mobilize tumor cell glycogen to promote proliferation and metastasis. Cell metabolism, 29(1), pp.141-155.


Liu, X., Cooper, D.E., Cluntun, A.A., Warmoes, M.O., Zhao, S., Reid, M.A., Liu, J., Lund, P.J., Lopes, M., Garcia, B.A. and Wellen, K.E., 2018. Acetate production from glucose and coupling to mitochondrial metabolism in mammals. Cell, 175(2), pp.502-513.


Stone, O.A., El-Brolosy, M., Wilhelm, K., Liu, X., Romão, A.M., Grillo, E., Lai, J.K., Günther, S., Jeratsch, S., Kuenne, C. and Lee, I.C., 2018. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature communications, 9(1), p.4077.


Dai, Z. and Locasale, J.W., 2018. Thermodynamic constraints on the regulation of metabolic fluxes. Journal of Biological Chemistry, 293(51), pp.19725-19739.


Johnson, M.O., Wolf, M.M., Madden, M.Z., Andrejeva, G., Sugiura, A., Contreras, D.C., Maseda, D., Liberti, M.V., Paz, K., Kishton, R.J. and Johnson, M.E., 2018. Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism. Cell, 175(7), pp.1780-1795.


Sanderson, S. M., & Locasale, J. W. (2018). Revisiting the Warburg Effect: Some Tumors Hold Their Breath. Cell metabolism, 28(5), 669-670.


Lu, M., Sanderson, S.M., Zessin, A., Ashcraft, K.A., Jones, L.W., Dewhirst, M.W., Locasale, J.W. and Hsu, D.S., 2018. Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer. Cancer & metabolism, 6(1), p.14.


Reid, M.A., Allen, A.E., Liu, S., Liberti, M.V., Liu, P., Liu, X., Dai, Z., Gao, X., Wang, Q., Liu, Y. and Lai, L., 2018. Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. Nature communications, 9(1), p.5442.



Glass, O.K., Bowie, M., Fuller, J., Darr, D., Usary, J., Boss, K., Choudhury, K.R., Liu, X., Zhang, Z., Locasale, J.W. and Williams, C., 2017. Differential response to exercise in claudin-low breast cancer. Oncotarget, 8(60), p.100989.


Singleton, K.R., Crawford, L., Tsui, E., Manchester, H.E., Maertens, O., Liu, X., Liberti, M.V., Magpusao, A.N., Stein, E.M., Tingley, J.P. and Frederick, D.T., 2017. Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence. Cell reports, 21(10), pp.2796-2812.


Reid, M.A., Paik, J. and Locasale, J.W., 2017. A missing link to vitamin B12 metabolism. Cell, 171(4), pp.736-737.


Reid, M.A., Dai, Z. and Locasale, J.W., 2017. The impact of cellular metabolism on chromatin dynamics and epigenetics. Nature cell biology, 19(11), p.1298.


Mehrmohamadi, M., Jeong, S.H. and Locasale, J.W., 2017. Molecular features that predict the response to antimetabolite chemotherapies. Cancer & metabolism, 5(1), p.8.


Tang, S., Fang, Y., Huang, G., Xu, X., Padilla‐Banks, E., Fan, W., Xu, Q., Sanderson, S.M., Foley, J.F., Dowdy, S. and McBurney, M.W., 2017. Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development. The EMBO journal, 36(21), pp.3175-3193.


Hershberger, K.A., Abraham, D.M., Martin, A.S., Mao, L., Liu, J., Gu, H., Locasale, J.W. and Hirschey, M.D., 2017. Sirtuin 5 is required for mouse survival in response to cardiac pressure overload. Journal of Biological Chemistry, 292(48), pp.19767-19781.


Liberti, M.V., Dai, Z., Wardell, S.E., Baccile, J.A., Liu, X., Gao, X., Baldi, R., Mehrmohamadi, M., Johnson, M.O., Madhukar, N.S. and Shestov, A.A., 2017. A predictive model for selective targeting of the Warburg effect through GAPDH inhibition with a natural product. Cell metabolism, 26(4), pp.648-659.


Liu, X. and Locasale, J.W., 2017. Biochemistry: A toxin that fuels metabolism. Nature, 548(7669), p.533.


Martin, A.S., Abraham, D.M., Hershberger, K.A., Bhatt, D.P., Mao, L., Cui, H., Liu, J., Liu, X., Muehlbauer, M.J., Grimsrud, P.A. and Locasale, J.W., 2017. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model. JCI insight, 2(14).


Salerno Jr, S., Mehrmohamadi, M., Liberti, M.V., Wan, M., Wells, M.T., Booth, J.G. and Locasale, J.W., 2017. RRmix: A method for simultaneous batch effect correction and analysis of metabolomics data in the absence of internal standards. PloS one, 12(6), p.e0179530.


Garcia, J., Bagwell, J., Njaine, B., Norman, J., Levic, D.S., Wopat, S., Miller, S.E., Liu, X., Locasale, J.W., Stainier, D.Y. and Bagnat, M., 2017. Sheath cell invasion and trans-differentiation repair mechanical damage caused by loss of caveolae in the zebrafish notochord. Current Biology, 27(13), pp.1982-1989.


Liu, X. and Locasale, J.W., 2017. Metabolomics reveals intratumor heterogeneity–Implications for precision medicine. EBioMedicine, 19, pp.4-5.


Wang, X., Yang, K., Xie, Q., Wu, Q., Mack, S.C., Shi, Y., Kim, L.J., Prager, B.C., Flavahan, W.A., Liu, X. and Singer, M., 2017. Purine synthesis promotes maintenance of brain tumor initiating cells in glioma. Nature neuroscience, 20(5), p.661.


Cluntun, A.A., Lukey, M.J., Cerione, R.A. and Locasale, J.W., 2017. Glutamine metabolism in cancer: understanding the heterogeneity. Trends in cancer, 3(3), pp.169-180.


Liu, X. and Locasale, J.W., 2017. Metabolomics: a primer. Trends in biochemical sciences, 42(4), pp.274-284.


Dai, Z. and Locasale, J.W., 2017. Metabolic pattern formation in the tumor microenvironment. Molecular systems biology, 13(2), p.915.


McDonald, O.G., Li, X., Saunders, T., Tryggvadottir, R., Mentch, S.J., Warmoes, M.O., Word, A.E., Carrer, A., Salz, T.H., Natsume, S. and Stauffer, K.M., 2017. Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis. Nature genetics, 49(3), p.367.



Wang, Q., Liberti, M.V., Liu, P., Deng, X., Liu, Y., Locasale, J.W. and Lai, L., 2017. Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell chemical biology, 24(1), pp.55-65.


Gao, X. and Locasale, J.W., 2016. Serine metabolism links tumor suppression to the epigenetic landscape. Cell metabolism, 24(6), pp.777-779.


Mehrmohamadi, M., Mentch, L.K., Clark, A.G. and Locasale, J.W., 2016. Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. Nature communications, 7, p.13666.


Mattocks, D.A., Mentch, S.J., Shneyder, J., Ables, G.P., Sun, D., Richie Jr, J.P., Locasale, J.W. and Nichenametla, S.N., 2017. Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice. Experimental gerontology, 88, pp.1-8.


Liu, X., Romero, I.L., Litchfield, L.M., Lengyel, E. and Locasale, J.W., 2016. Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers. Cell metabolism, 24(5), pp.728-739.


Gerriets, V.A., Kishton, R.J., Johnson, M.O., Cohen, S., Siska, P.J., Nichols, A.G., Warmoes, M.O., de Cubas, A.A., MacIver, N.J., Locasale, J.W. and Turka, L.A., 2016. Foxp3 and Toll-like receptor signaling balance T reg cell anabolic metabolism for suppression. Nature immunology, 17(12), p.1459.


Dai, Z. and Locasale, J.W., 2017. Understanding metabolism with flux analysis: From theory to application. Metabolic engineering, 43, pp.94-102.


Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G., Brown, S.A., Cloer, C., Kishton, R.J., Gao, X., Youngblood, B. and Do, M., 2016. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation. Immunity, 45(3), pp.540-554.


Gao, X., Reid, M.A., Kong, M. and Locasale, J.W., 2017. Metabolic interactions with cancer epigenetics. Molecular aspects of medicine, 54, pp.50-57.


Pan, M., Reid, M.A., Lowman, X.H., Kulkarni, R.P., Tran, T.Q., Liu, X., Yang, Y., Hernandez-Davies, J.E., Rosales, K.K., Li, H. and Hugo, W., 2016. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nature cell biology, 18(10), p.1090.


Dai, Z., Shestov, A.A., Lai, L. and Locasale, J.W., 2016. A flux balance of glucose metabolism clarifies the requirements of the Warburg effect. Biophysical journal, 111(5), pp.1088-1100.


Reid, M.A., Lowman, X.H., Pan, M., Tran, T.Q., Warmoes, M.O., Gabra, M.B.I., Yang, Y., Locasale, J.W. and Kong, M., 2016. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes & development, 30(16), pp.1837-1851.


Liberti, M.V. and Locasale, J.W., 2016. Metabolism: A new layer of glycolysis. Nature chemical biology, 12(8), p.577.


Ser, Z., Gao, X., Johnson, C., Mehrmohamadi, M., Liu, X., Li, S. and Locasale, J.W., 2016. Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow. Cell reports, 15(11), pp.2367-2376.


Torrano, V., Valcarcel-Jimenez, L., Cortazar, A.R., Liu, X., Urosevic, J., Castillo-Martin, M., Fernández-Ruiz, S., Morciano, G., Caro-Maldonado, A., Guiu, M. and Zúñiga-García, P., 2016. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nature cell biology, 18(6), p.645.


Kishton, R.J., Barnes, C.E., Nichols, A.G., Cohen, S., Gerriets, V.A., Siska, P.J., Macintyre, A.N., Goraksha-Hicks, P., de Cubas, A.A., Liu, T. and Warmoes, M.O., 2016. AMPK is essential to balance glycolysis and mitochondrial metabolism to control T-ALL cell stress and survival. Cell metabolism, 23(4), pp.649-662.


Sadhukhan, S., Liu, X., Ryu, D., Nelson, O.D., Stupinski, J.A., Li, Z., Chen, W., Zhang, S., Weiss, R.S., Locasale, J.W. and Auwerx, J., 2016. Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function. Proceedings of the National Academy of Sciences, 113(16), pp.4320-4325.


Park, S., Chang, C.Y., Safi, R., Liu, X., Baldi, R., Jasper, J.S., Anderson, G.R., Liu, T., Rathmell, J.C., Dewhirst, M.W. and Wood, K.C., 2016. ERRα-regulated lactate metabolism contributes to resistance to targeted therapies in breast cancer. Cell reports, 15(2), pp.323-335.


Niewiadomski, J., Zhou, J.Q., Roman, H.B., Liu, X., Hirschberger, L.L., Locasale, J.W. and Stipanuk, M.H., 2016. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Annals of the New York Academy of Sciences, 1363(1), pp.99-115.


Liberti, M.V. and Locasale, J.W., 2016. The Warburg effect: how does it benefit cancer cells?. Trends in biochemical sciences, 41(3), pp.211-218.


Sumita, K., Lo, Y.H., Takeuchi, K., Senda, M., Kofuji, S., Ikeda, Y., Terakawa, J., Sasaki, M., Yoshino, H., Majd, N. and Zheng, Y., 2016. The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis. Molecular cell, 61(2), pp.187-198.



Mentch, S.J. and Locasale, J.W., 2016. One‐carbon metabolism and epigenetics: understanding the specificity. Annals of the New York Academy of Sciences, 1363(1), pp.91-98.


Jurkowska, H., Niewiadomski, J., Hirschberger, L.L., Roman, H.B., Mazor, K.M., Liu, X., Locasale, J.W., Park, E. and Stipanuk, M.H., 2016. Downregulation of hepatic betaine: homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. Amino acids, 48(3), pp.665-676.


Hirschey, M.D., DeBerardinis, R.J., Diehl, A.M.E., Drew, J.E., Frezza, C., Green, M.F., Jones, L.W., Ko, Y.H., Le, A., Lea, M.A. and Locasale, J.W., 2015, December. Dysregulated metabolism contributes to oncogenesis. In Seminars in cancer biology (Vol. 35, pp. S129-S150). Academic Press.


Mentch, S.J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D., Padilla, P.G., Ables, G., Bamman, M.M., Thalacker-Mercer, A.E. and Nichenametla, S.N., 2015. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell metabolism, 22(5), pp.861-873.


Simões, R.V., Serganova, I.S., Kruchevsky, N., Leftin, A., Shestov, A.A., Thaler, H.T., Sukenick, G., Locasale, J.W., Blasberg, R.G., Koutcher, J.A. and Ackerstaff, E., 2015. Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment. Neoplasia, 17(8), pp.671-684.


Cluntun, A.A., Huang, H., Dai, L., Liu, X., Zhao, Y. and Locasale, J.W., 2015. The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer & metabolism, 3(1), p.10.


Barker, B.E., Sadagopan, N., Wang, Y., Smallbone, K., Myers, C.R., Xi, H., Locasale, J.W. and Gu, Z., 2015. A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data. Computational biology and chemistry, 59, pp.98-112.


Ho, P.C., Bihuniak, J.D., Macintyre, A.N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.C., Cui, G., Micevic, G., Perales, J.C. and Kleinstein, S.H., 2015. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell, 162(6), pp.1217-1228.


Colak, G., Pougovkina, O., Dai, L., Tan, M., te Brinke, H., Huang, H., Cheng, Z., Park, J., Wan, X., Liu, X. and Yue, W.W., 2015. Proteomic and biochemical studies of lysine malonylation suggest its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation. Molecular & Cellular Proteomics, 14(11), pp.3056-3071.


Chourasia, A.H., Tracy, K., Frankenberger, C., Boland, M.L., Sharifi, M.N., Drake, L.E., Sachleben, J.R., Asara, J.M., Locasale, J.W., Karczmar, G.S. and Macleod, K.F., 2015. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO reports, 16(9), pp.1145-1163.


Douris, N., Melman, T., Pecherer, J.M., Pissios, P., Flier, J.S., Cantley, L.C., Locasale, J.W. and Maratos-Flier, E., 2015. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(10), pp.2056-2065.


Liu, X., Sadhukhan, S., Sun, S., Wagner, G.R., Hirschey, M.D., Qi, L., Lin, H. and Locasale, J.W., 2015. High-resolution metabolomics with Acyl-CoA profiling reveals widespread remodeling in response to diet. Molecular & cellular proteomics, 14(6), pp.1489-1500.


Buescher, J.M., Antoniewicz, M.R., Boros, L.G., Burgess, S.C., Brunengraber, H., Clish, C.B., DeBerardinis, R.J., Feron, O., Frezza, C., Ghesquiere, B. and Gottlieb, E., 2015. A roadmap for interpreting 13C metabolite labeling patterns from cells. Current opinion in biotechnology, 34, pp.189-201.


Madhukar, N.S., Warmoes, M.O. and Locasale, J.W., 2015. Organization of enzyme concentration across the metabolic network in cancer cells. PloS one, 10(1), p.e0117131.


Ser, Z., Liu, X., Tang, N.N. and Locasale, J.W., 2015. Extraction parameters for metabolomics from cell extracts. Analytical biochemistry, 475, p.22.


Chen, J., Lee, H.J., Wu, X., Huo, L., Kim, S.J., Xu, L., Wang, Y., He, J., Bollu, L.R., Gao, G. and Su, F., 2015. Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. Cancer research, 75(3), pp.554-565.


Mehrmohamadi, M. and Locasale, J.W., 2015. Context-dependent utilization of serine in cancer. Molecular & cellular oncology, 2(4), p.e996418.


Gerriets, V.A., Kishton, R.J., Nichols, A.G., Macintyre, A.N., Inoue, M., Ilkayeva, O., Winter, P.S., Liu, X., Priyadharshini, B., Slawinska, M.E. and Haeberli, L., 2015. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. The Journal of clinical investigation, 125(1), pp.194-207.



Johnson, C., Chen, K.Y., Liu, X., Bu, P., Locasale, J. and Shen, X., 2014. A metabolic signature of colon cancer initiating cells. Cancer & metabolism, 2(1), p.P32.


Huang, L., Kim, D., Liu, X., Myers, C.R. and Locasale, J.W., 2014. Estimating relative changes of metabolic fluxes. PLoS computational biology, 10(11), p.e1003958.


Mehrmohamadi, M., Liu, X., Shestov, A.A. and Locasale, J.W., 2014. Characterization of the usage of the serine metabolic network in human cancer. Cell reports, 9(4), pp.1507-1519.


Liu, T., Kishton, R.J., Macintyre, A.N., Gerriets, V.A., Xiang, H., Liu, X., Abel, E.D., Rizzieri, D., Locasale, J.W. and Rathmell, J.C., 2014. Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. Cell death & disease, 5(10), p.e1470.


Warmoes, M.O. and Locasale, J.W., 2014. Heterogeneity of glycolysis in cancers and therapeutic opportunities. Biochemical pharmacology, 92(1), pp.12-21.


Shestov, A.A., Liu, X., Ser, Z., Cluntun, A.A., Hung, Y.P., Huang, L., Kim, D., Le, A., Yellen, G., Albeck, J.G. and Locasale, J.W., 2014. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. Elife, 3, p.e03342.


Liu, X., Ser, Z., Cluntun, A.A., Mentch, S.J. and Locasale, J.W., 2014. A strategy for sensitive, large scale quantitative metabolomics. JoVE (Journal of Visualized Experiments), (87), p.e51358.


Dasgupta, T., Croll, D.H., Owen, J.A., Vander Heiden, M.G., Locasale, J.W., Alon, U., Cantley, L.C. and Gunawardena, J., 2014. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. Journal of Biological Chemistry, 289(19), pp.13010-13025.


Sun, S., Shi, G., Han, X., Francisco, A.B., Ji, Y., Mendonça, N., Liu, X., Locasale, J.W., Simpson, K.W., Duhamel, G.E. and Kersten, S., 2014. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proceedings of the National Academy of Sciences, 111(5), pp.E582-E591.


Liu, X., Ser, Z. and Locasale, J.W., 2014. Development and quantitative evaluation of a high-resolution metabolomics technology. Analytical chemistry, 86(4), pp.2175-2184.



Parkhitko, A.A., Priolo, C., Coloff, J.L., Yun, J., Wu, J.J., Mizumura, K., Xu, W., Malinowska, I.A., Yu, J., Kwiatkowski, D.J. and Locasale, J.W., 2014. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Molecular Cancer Research, 12(1), pp.48-57.


Johnson, C., Warmoes, M.O., Shen, X. and Locasale, J.W., 2015. Epigenetics and cancer metabolism. Cancer letters, 356(2), pp.309-314.


Locasale, J.W., 2013. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nature Reviews Cancer, 13(8), p.572.


Shestov, A.A., Barker, B., Gu, Z. and Locasale, J.W., 2013. Computational approaches for understanding energy metabolism. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6), pp.733-750.


Hu, J., Locasale, J.W., Bielas, J.H., O'sullivan, J., Sheahan, K., Cantley, L.C., Vander Heiden, M.G. and Vitkup, D., 2013. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature biotechnology, 31(6), p.522.



Baker, R., Lewis, S.M., Sasaki, A.T., Wilkerson, E.M., Locasale, J.W., Cantley, L.C., Kuhlman, B., Dohlman, H.G. and Campbell, S.L., 2013. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nature structural & molecular biology, 20(1), p.46.


Shyh-Chang, N., Locasale, J.W., Lyssiotis, C.A., Zheng, Y., Teo, R.Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J.J., Zhu, H. and Asara, J.M., 2013. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science, 339(6116), pp.222-226.


Locasale, J.W., 2012. The consequences of enhanced cell-autonomous glucose metabolism. Trends in Endocrinology & Metabolism, 23(11), pp.545-551.


Locasale, J.W., 2012. Metabolic rewiring drives resistance to targeted cancer therapy. Molecular systems biology, 8(1), p.597.


Yun, J., Johnson, J.L., Hanigan, C.L. and Locasale, J.W., 2012. Interactions between epigenetics and metabolism in cancers. Frontiers in oncology, 2, p.163.


Ying, H., Kimmelman, A.C., Lyssiotis, C.A., Hua, S., Chu, G.C., Fletcher-Sananikone, E., Locasale, J.W., Son, J., Zhang, H., Coloff, J.L. and Yan, H., 2012. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell, 149(3), pp.656-670.


Locasale, J.W., Melman, T., Song, S., Yang, X., Swanson, K.D., Cantley, L.C., Wong, E.T. and Asara, J.M., 2012. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Molecular & Cellular Proteomics, 11(6), pp.M111-014688.


Lyssiotis, C.A., Anastasiou, D., Locasale, J.W., Vander Heiden, M.G., Christofk, H.R. and Cantley, L.C., 2012. Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth. Biomedical Journal, 23, pp.213-217.


Locasale, J.W. and Zeskind, B.J., 2011. Maximizing the efficacy of angiogenesis inhibitors. Journal of Clinical Oncology, 30(3), pp.337-338.



Vander Heiden, M.G., Lunt, S.Y., Dayton, T.L., Fiske, B.P., Israelsen, W.J., Mattaini, K.R., Vokes, N.I., Stephanopoulos, G., Cantley, L.C., Metallo, C.M. and Locasale, J.W., 2011, January. Metabolic pathway alterations that support cell proliferation. In Cold Spring Harbor symposia on quantitative biology (Vol. 76, pp. 325-334). Cold Spring Harbor Laboratory Press.


Shyh‐Chang, N., Zheng, Y., Locasale, J.W. and Cantley, L.C., 2011. Human pluripotent stem cells decouple respiration from energy production. The EMBO journal, 30(24), pp.4851-4852.


Mullarky, E., Mattaini, K.R., Vander Heiden, M.G., Cantley, L.C. and Locasale, J.W., 2011. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment cell & melanoma research, 24(6), pp.1112-1115.


Locasale, J.W. and Cantley, L.C., 2011. Genetic selection for enhanced serine metabolism in cancer development.


Locasale, J.W. and Cantley, L.C., 2011. Metabolic flux and the regulation of mammalian cell growth. Cell metabolism, 14(4), pp.443-451.


Locasale, J.W. and Zeskind, B., 2011. IL-6 and Ovarian Cancer. Clinical Cancer Research, 17(24), pp.7837-7837.


Gao, D., Inuzuka, H., Tan, M.K.M., Fukushima, H., Locasale, J.W., Liu, P., Wan, L., Zhai, B., Chin, Y.R., Shaik, S. and Lyssiotis, C.A., 2011. mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR. Molecular cell, 44(2), pp.290-303.


Locasale, J.W., Grassian, A.R., Melman, T., Lyssiotis, C.A., Mattaini, K.R., Bass, A.J., Heffron, G., Metallo, C.M., Muranen, T., Sharfi, H. and Sasaki, A.T., 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature genetics, 43(9), p.869.


Anastasiou, D., Poulogiannis, G., Asara, J.M., Boxer, M.B., Jiang, J.K., Shen, M., Bellinger, G., Sasaki, A.T., Locasale, J.W., Auld, D.S. and Thomas, C.J., 2011. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science, 334(6060), pp.1278-1283.


Caroline, H.Y., Pan, H., Seebacher, J., Jang, I.H., Hyberts, S.G., Heffron, G.J., Vander Heiden, M.G., Yang, R., Li, F., Locasale, J.W. and Sharfi, H., 2011. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell, 146(4), pp.607-620.


Sasaki, A.T., Carracedo, A., Locasale, J.W., Anastasiou, D., Takeuchi, K., Kahoud, E.R., Haviv, S., Asara, J.M., Pandolfi, P.P. and Cantley, L.C., 2011. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci. Signal., 4(163), pp.ra13-ra13.




Locasale, J.W., Vander Heiden, M.G. and Cantley, L.C., 2010. Rewiring of glycolysis in cancer cell metabolism.


Vander Heiden, M.G., Locasale, J.W., Swanson, K.D., Sharfi, H., Heffron, G.J., Amador-Noguez, D., Christofk, H.R., Wagner, G., Rabinowitz, J.D., Asara, J.M. and Cantley, L.C., 2010. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science, 329(5998), pp.1492-1499.


Locasale, J.W. and Cantley, L.C., 2010. Altered metabolism in cancer. BMC biology, 8(1), p.88.


Prisic, S., Dankwa, S., Schwartz, D., Chou, M.F., Locasale, J.W., Kang, C.M., Bemis, G., Church, G.M., Steen, H. and Husson, R.N., 2010. Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Proceedings of the National Academy of Sciences, 107(16), pp.7521-7526.

Locasale, J.W., Cantley, L.C. and Vander Heiden, M.G., 2009. Cancer's insatiable appetite. Nature biotechnology, 27(10), p.916.


Locasale, J.W. and Wolf-Yadlin, A., 2009. Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data. PloS one, 4(8), p.e6522.


Locasale, J.W., Napoli, A.A., Chen, S., Berman, H.M. and Lawson, C.L., 2009. Signatures of protein-DNA recognition in free DNA binding sites. Journal of molecular biology, 386(4), pp.1054-1065.



Locasale, J.W., 2008. Three-state kinetic mechanism for scaffold-mediated signal transduction. Physical Review E, 78(5), p.051921.


Locasale, J.W., 2008. Signal duration and the time scale dependence of signal integration in biochemical pathways. BMC systems biology, 2(1), p.108.


Locasale, J.W. and Chakraborty, A.K., 2008. Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. PLoS computational biology, 4(6), p.e1000099.


Locasale, J.W., 2008. Allovalency revisited: An analysis of multisite phosphorylation and substrate rebinding. The Journal of chemical physics, 128(11), p.03B614.



Locasale, J.W., Shaw, A.S. and Chakraborty, A.K., 2007. Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proceedings of the National Academy of Sciences, 104(33), pp.13307-13312.


Locasale, J.W., 2007. Computational investigations into the origins of short-term biochemical memory in T cell activation. PloS one, 2(7), p.e627.


Čemerski, S., Das, J., Locasale, J., Arnold, P., Giurisato, E., Markiewicz, M.A., Fremont, D., Allen, P.M., Chakraborty, A.K. and Shaw, A.S., 2007. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity, 26(3), pp.345-355.


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Locasale Lab - Duke University School of Medicine 

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