
ABOUT US
Our lab is part of the Department of Pharmacology and Cancer Biology at Duke University. We are also members of a number of Research Institutes, Centers, and Programs at Duke. We accept graduate students from a number of places including but not limited to Cell and Molecular Biology, Computational Biology and Bioinformatics, the Medical Sciences Training Program, Pharmacology, and Molecular Cancer Biology.
We have a longstanding interesting in understanding the structure and function of metabolic networks in health and pathology, particularly cancer. We are particularly interested in how diet and nutrition shape metabolic pathways and how metabolism influences epigenetics and chromatin biology. The development and application of metabolomics approaches form the core of our research.
We are a diverse group with equally diverse skills in analytical chemistry, genetics, computational biology, mathematics, cell biology, and biochemistry allowing us to solve complex biological problems with an integrative and collaborative approach.
RESEARCH AREAS

The role of diet
and nutrition in shaping metabolic networks
SPECIFIC INTERRELATED AREAS

Quantitive biology of metabolism

The impact of cellular metabolism on chromatin biology and epigenetics
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The Serine, Glycine, One Carbon (SGOC) Network
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Methionine metabolism
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Glucose Metabolism and the Warburg Effect
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Central Carbon Metabolism and Mitochondrial Biology
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Targeting Metabolism for Cancer Therapy and Prevention
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Mass Spectrometry and Bioinformatics Technology
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Computational Approaches for Understanding Metabolic Networks and Regulation
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Modeling Gene-Environment Interactions in Metabolism
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Immunometabolism
DR. JASON LOCASALE
Dr. Locasale completed his B.A. in Chemistry from Rutgers, his PhD in Biological Engineering from MIT, and his postdoc at Harvard Medical School. He was a professor at Cornell University before joining the Department of Pharmacology and Cancer Biology at Duke University. He is widely regarded as a leader in the field of metabolic research, with a focus on cancer metabolism.
CONTACT US
Jason Locasale
E-mail: dr.jason.locasale [at] gmail [dot] com
Phone: office: (919) 684-9309
lab: (919) 681-6210
Office: LSRC C270
Mail:
Duke University School of Medicine
Department of Pharmacology and Cancer Biology
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The Lab
Levine Science Research Center, C270, Box 3813
Durham, NC 27710
Phone: lab: (919) 681-6210
Location: LSRC C264
Mail:
Duke University School of Medicine
Department of Pharmacology and Cancer Biology
Levine Science Research Center C266, Box 3813
Durham, NC 27710